Schmid, A. suggest that activation of insulin and IGF1 receptors on pancreatic malignancy cells is definitely induced through paracrine macrophage-derived IGF1/IGF2 signaling. Interestingly, on the other hand (IL4) triggered M2 macrophages indicated higher levels of IGFs compared with classically (IFN/LPS) triggered M1 macrophages (Supplementary Fig. S1C and S1D). Immunoblotting analysis of Match-2 human being pancreatic … Continue reading Schmid, A